Figure 2.

(A) The sequence of human AIM1. Protein sequence is shown in single-letter code. Relative positions of introns in the AIM1 gene are marked by vertical lines. The 12 βγ motifs are numbered and indicated by colored boxes. A-type motifs are blue and B-type motifs are red. Short underlines indicate connecting peptides between predicted structural domains. Gray shading indicates the position of the two novel linker peptides. (B) Schematic of the complete AIM1 gene is shown with shaded portions representing coding sequence and splicing as indicated. For the 7.2-kb AIM1 transcript, a large first exon is followed by 17 smaller exons. The 4.1-kb AIM1 transcript begins just upstream of the second exon, probably beginning with an unidentified, 20- to 30-bp first exon containing a translation start codon.