Figure 4.

Modeling the βγ motifs of AIM1. (A and B) schematics of pseudo-threefold AIM1 structures. (A) β-like conformation with “straight” connecting peptides shown as dotted line. (B) γ-Like conformation with “bent” interdomain-connecting peptides. (C) A conceptual illustration of the pseudo-threefold structure. Pairs of domains from the βB2 structure [Bax et al. (24)] were assembled at separations consistent with the lengths of connecting peptides. Nonhydrogen atoms are shown in a van der Waals representation.