. 1997 Apr 1;94(7):3235–3239. doi: 10.1073/pnas.94.7.3235

Table 2.

Effect of ethanol dose and duration of treatment on reperfusion injury

Time	Ethanol, %	n	Developed pressure, mmHg		Diastolic pressure, mmHg		CK, units/ml per heart gram-dry-weight
Time	Ethanol, %	n	Preischemia	Reperfusion	Preischemia	Reperfusion	CK, units/ml per heart gram-dry-weight
3 weeks	10	6	113 ± 4	62 ± 4^*	10	16 ± 1^*	156 ± 22^*
	5	6	111 ± 3	39 ± 6	10	34 ± 3^*	328 ± 76
	2.5	6	112 ± 4	38 ± 7	10	38 ± 2^*	348 ± 67
	Control	6	115 ± 3	31 ± 7	10	57 ± 7	400 ± 60
6 weeks	20	10	118 ± 5	55 ± 4^*	10	26 ± 6^*	204 ± 42^*
	10	10	116 ± 3	60 ± 2^*	10	22 ± 2^*	159 ± 25^*
	5	6	113 ± 7	55 ± 4^*	10	17 ± 2^*	187 ± 33^*
	2.5	6	105 ± 7	66 ± 7^*	10	18 ± 4^*	252 ± 20^*
	Control	10	112 ± 4	35 ± 3	10	46 ± 4	356 ± 26

12 weeks	20	8	116 ± 6	56 ± 5^*	10	26 ± 6^*	181 ± 29^*
PC	0	6	116 ± 4	62 ± 6^*	10	26 ± 4^*	167 ± 2^*

LV-developed and diastolic pressures and release of CK were measured during postischemic reperfusion. Experiments were performed as described in Table 1 in hearts isolated from guinea pigs consuming varying concentrations of ethanol in their drinking water for 3, 6, or 12 weeks. A group of hearts from animals not exposed to ethanol were subjected to ischemic preconditioning (PC). Data are presented as mean(SEM).

P < 0.05 versus control.