Figure 2.

Lymph nodes and spleen from A-myb transgenic mice are enlarged compared with wild-type littermates. (A) Lymph nodes from A-myb transgenic mice are hypercellular. Biopsied lymph nodes were counted to determine the total number of lymphocytes per lymph node. Data were collected from 11 control and 18 transgenic mice between 9 and 15 months of age. The increase in cellularity observed in A-myb transgenic lymph nodes is statistically significant (P < 0.02, Student’s t test). (B) Transgenic spleens are heavier than control spleens. The weight of transgenic and control spleens are expressed as a percentage of total body mass. Transgenic spleens were 2.5-fold heavier than wild-type spleens, representing a mean increase of 250%. Data were collected from 13 transgenic and 13 wild-type littermates between the ages of 9 and 15 months. The increase in splenic mass is statistically significant (P < 0.05, Student’s t test).