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. Author manuscript; available in PMC: 2008 Oct 15.
Published in final edited form as: Arch Biochem Biophys. 2007 Jun 28;466(2):260–266. doi: 10.1016/j.abb.2007.06.016

Fig. 2.

Fig. 2

(a) Bisabolyl carbocation intermediate in trichodiene synthase catalysis. (b) R-Azabisabolene, a cationic analogue of the bisabolyl cation in the trichodiene synthase mechanism, is a strong competitive inhibitor in the presence of inorganic diphosphate (PPi) with Ki for PPi = 0.51 μM and an induced inhibition constant of 2.6 μM [10]. (c) The aza analogue of the α-terpinyl cation is a competitive inhibitor in the presence of inorganic pyrophosphate (PPi) with Ki for PPi = 0.48 μM and an induced inhibition constant of 10.9 μM [10]. (d) The benzyl triethylammonium cation (BTAC) is a phase transfer catalyst for synthetic organic chemistry that partially mimics the bisabolyl carbocation intermediate (a).