Table 1.
Odds ratio of prostate cancer by length of CAG repeat length of the AR gene among men in the Physicians’ Health Study (1982–1995)
| CAG length
|
P value (trend) | |||||||
|---|---|---|---|---|---|---|---|---|
| ≥26 | 24–25 | 22–23 | 21 | 20 | 19 | ≤18 | ||
| Controls | 72 | 115 | 119 | 101 | 65 | 61 | 55 | |
| Total prostate cancer (n) | 60 | 98 | 116 | 113 | 69 | 62 | 69 | |
| OR* | 1.0 | 1.02 | 1.17 | 1.35 | 1.28 | 1.22 | 1.52 | 0.04 |
| 95% CI | (0.66–1.58) | (0.76–1.80) | (0.87–2.09) | (0.79–2.08) | (0.75–2.00) | (0.92–2.49) | ||
| High grade/stage prostate cancer (n)† | 24 | 37 | 47 | 55 | 38 | 30 | 38 | |
| OR* | 1.0 | 0.99 | 1.20 | 1.65 | 1.79 | 1.49 | 2.14 | 0.001 |
| 95% CI | (0.55–1.80) | (0.68–2.14) | (0.93–2.92) | (0.97–3.32) | (0.79–2.82) | (1.14–4.01) | ||
| Low grade/stage prostate cancer (n) | 35 | 58 | 69 | 58 | 30 | 31 | 28 | |
| OR* | 1.0 | 1.03 | 1.20 | 1.18 | 0.94 | 1.06 | 1.03 | 0.86 |
| 95% CI | (0.61–1.99) | (0.72–1.99) | (0.70–1.99) | (0.52–1.71) | (0.58–1.92) | (0.56–1.91) | ||
*
Odds ratio (OR) and 95% CI for various categories of CAG repeats relative to men with repeat size ≤19. OR controlled for age (in 5-year age categories) and smoking (past, current) by unconditional logistic regression.
†
Tumors with Gleason grade ≥7 or high grade, or those with extension outside the prostate gland (stage C or D).