Figure 6.

PDE1C2, ACIII, and PDE4A are expressed in the same neurons; however, their subcellular distribution is distinct. (A and B) Unmerged image of PDE1C2 and ACIII, respectively. (C) Merged image of PDE1C2 and ACIII. PDE1C2 and ACIII appear to be colocalized in the same cilia. The arrows point to a tuft of cilia emerging from a single neuron. (D and E) Unmerged image of PDE4A and PDE1C2, respectively. (F) Merged image of PDE4A and PDE1C2. Cilia expressing PDE1C2 are seen emerging from neurons expressing PDE4A (arrows), suggesting that although these proteins are found in the same neurons their subcellular distribution is distinct. (Bar = 10 μm.)