Figure 6.

Voltage dependence of the deactivation time course of the Δ501–677 channel. (A) Tail currents for KAT1 wild-type (Left) and the Δ501–677 channel (Right) were recorded at −130 to 30 mV for KAT1 wild-type or −140 to 30 mV for Δ501–677 following an activating pulse to −140 mV (wild type) or −150 mV (Δ501–677). (B) Tail currents derived as shown in A were fitted with a sum of two exponentials. The fast deactivation time constants are plotted against the voltage. Solid lines represent simple exponential fits of the voltage dependence of the time constants. (KAT1 wild type = □, z_{C □} = 0.55 ± 0.06, n = 8; Δ501–677 channel = ▪, z_{C ▪} = 0.28 ± 0.05, n = 2).