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. Author manuscript; available in PMC: 2007 Dec 1.
Published in final edited form as: Neuroscience. 2006 Oct 23;143(2):351–375. doi: 10.1016/j.neuroscience.2006.09.019

Figure 4.

Figure 4

Subcellular and subsynaptic localization of group I mGluRs in the basal ganglia. A: A dendrite (den) in the monkey STN displays perisynaptic immunogold labeling for mGluR5 (small arrows) at a symmetric synapse (arrowhead) formed by a GABA-containing terminal (GABA+), and at an asymmetric synapse (large arrow) formed by a GABA-negative terminal (GABA−). From Kuwajima et al., 2004b, with permission B: Immunoreactivity for mGluR5 (white arrowheads) in the monkey GP is expressed within the postsynaptic specialization of symmetric axo-dendritic synapses established by putative striatal terminals (AT1, AT2). From Hanson and Smith, 1999, with permission. C: Immunoreactivity for mGluR5 (small arrows) in the monkey striatum is localized perisynaptically at a symmetric synapse (black arrowhead) established by a tyrosine hydroxylase-immunopositive (dopaminergic) axon terminal (TH+). From Paquet and Smith, 2003 with permission. D-E: Subcellular distribution of immunogold labeling for mGluR1a (D) and mGluR5 (E) in the rat SNr. Note that most mGluR1a labeling is apposed to the dendritic plasma membrane (D), whereas most of mGluR5 labeling is intracellular (E). From Hubert et al., 2001 with permission. F: In the monkey putamen, a biotin-dextran-amine-labeled terminal bouton (asterisk) from the centromedian nucleus of the thalamus contains mGluR1a immunogold labeling. From Paquet and Smith, 2003, with permission. G: Presynaptic mGluR1a immunogold labeling is also found in a TH-positive terminal (asterisk) in the monkey putamen. From Paquet and Smith, 2003, with permission. Abbreviations: AT, axonal terminal; den, dendrite; Ut, unlabeled terminal. Scale bars: A, 200 nm; B, 500 nm; C, 250 nm; D, 500 nm (valid for E); F, 500 nm; G, 250 nm.