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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Neuroimage. 2007 Mar 23;36(3):755–773. doi: 10.1016/j.neuroimage.2007.03.010

Fig. 1.

Fig. 1

Lesion development in the striatum and substantia nigra. Coronal brain sections 33 days after unilateral intrastriatal injection of 6-OHDA (n = 18) or vehicle (n = 15) processed with TH-immunohistochemical and hematoxylin staining. The loss of area of TH-positive staining (arrows) on the lesioned side was expressed as a percentage of the total intact area, as measured on the contralateral side, both for the striatum (1C) and substantia nigra (2C). No detectable loss of TH staining was noted in sham-lesioned rats both at the level of the striatum and substantia nigra. Measurements (±S.E.M.) were taken at +1.0 mm and -1.0 mm relative to bregma (striatum) and -5.8 mm relative to bregma (substantia nigra). *p < 0.0001 vs. control.