Table 2.

Regions of statistically significant differences of functional brain activation as determined by SPM analysis

Region	Lesion vs. sham		Locomotor vs. rest
	Rest (Ipsi/Contra)	Locomotor (Ipsi/Contra)	Lesion (Ipsi/Contra)	Sham (Ipsi/Contra)
Amygdala (BMA, BMP, MeA)	↓^/↓^	↓^*/-	↓^*/↓	↓^/↓^
Anterior commissures (aca)	↑/-	↓/↓	↓/-	↑^/↑^
Cerebellum (vermis)	Midline ↑	Midline ↑^*	Midline ↑^*	Midline ↑^*
Corpus callosum (cc)	Midline ↑^*	Midline ↓	-	Midline ↑^*
Dentate gyrus (PoDG, posterior)	-/↓^*	-	↓^*/-	↓^/↓^
External capsule (ec)	↑^/↑^	↓^/↓^	↑^/↑^	↑^/↑^
Forcepts minor (fmi)	↑^/↑^	↓/↓	-	↑^/↑^
Forcepts major (fmj)	↑^*/-	-	↑^/↑^	↑^/↑^
Globus pallidus, external (GPE)	-	↓^*/-	↓^*/-	-
Globus pallidus, internal (GPI)	↑^*/-	↓^*/-	↓^*/-	-
Hypothalamus, anterior (AH), posterior (PH), posterior lateral (PLH)	↓^/↓^	-/↑	-	↓^/↓^
Inferior colliculus, central n. (CIC)	↓/↓^*	-	-	↓^/↓^
Lateral lemniscus (VLL, ILL)	↓/↓^*	-/↑	↓^*/↓	↓^/↓^
Medial septal n. (MS)	-	-	Midline ↓	Midline ↓^*
Pretectal n. anterior (APT)	↓/↓^*	-	↓/↓	↓^/↓^
Pretectal n., posterior (PPT)	-	-	-	↓^/↓^
Raphe, median (MnR)	Midline ↓	-	Midline ↓	Midline ↓^*
Red n. (RPC)	-	↑/↑	-	↓^/↓^
Septal n., lateral-medial, triangular, septofimbrial (LSI, TS, SFi)	Midline ↑^*	-	-	Midline ↑^*
Septal n., lateral ventral (LSV)	-	↓/-	↓/↓	-
Striatum, anterior dorsolateral (CPu)	-	↓^*/-	-	↑^/↑^
Striatum, anterior centromedial (CPu)	↓^/↓^	↓^*/-	-	-
Striatum, posterior ventral (CPu)	-/↓^*	↓^*/-	↓^*/-	↓^/↓^
Subiculum, posterior, dorsal, (Post, DS)	-/↓^*	-/↑^*	-/↑^*	↓^/↓^
Parasubiculum/Coudomedial Entorhinal Cx (PaS, CEnt)
Subiculum, ventral (VS)	-	-/↑^*	-/↑	-
Substantia nigra, anterior (SN)	-	-/↑^*	-/↑	↓^/↓^
Subthalamic n. (STN)	↑^*/↑	-/↑^*	-/↑	↓^/↓^
Superior colliculus (SC)	↓/↓^*	↑/-	-	↓^/↓^
Supramammillary n. (SuM)	-	Midline ↑^*	-	Midline ↓^*
Thalamus, central, medial (CM)	Midline ↑	-	Midline ↓	Midline ↓^*
geniculate (medial, MG)	↓/↓^*	-	↓^*/-	↓^/↓^
lateral dorsal (LD)	↑^*/-	-	-	↑^/↑^
Lateral posterior (LP)	↓/↓^*	-	-	↓^/↓^
Reuinens n. (Re)	Midline ↓	Midline ↑		Midline ↓^*
Ventral lateral n. (VL)	↑^*/-	-	-	-
Ventral anterior n. (VA)	↑/-	-	-	-
Ventroposterior lateral (VPL)	↑/-	↑/↑	-	-
Ventroposterior medial (VPM)	↓/↓^*	-	↑/↑	↓^/↓^
Ventromedial, (VM)	↓^/↓^	↑^/↑^	-	↓^/↓^
Trigeminal n., motor, sensory, (5)	-	-/↑^*	↓/↑	↓/↓
Vestibular n., medial, superior (MVe, SuVe)	-	-/↑	-	↓/↓
Zona incerta	-	-/↑^*	-	↓^/↓^

Data are for rats with unilateral striatal lesions either at rest (Lesion + Rest, n = 9) or during a treadmill challenge (Lesion + Locomotor, n = 9), as well as for the corresponding sham-lesioned controls (Sham + Rest, n = 7; Sham + Locomotor, n = 8). Arrows denote increases or decreases in the group differences in cerebral blood flow tracer distribution (CBF-TR). Significance is for shown at the voxel level (p < 0.01).

designates additional significant at the cluster level with correction for multiple comparisons (p < 0.01, cluster ≥ 100 voxels).