Table 3.
Differentially expressed genes in leiomyomas compared to keloids/incesional scars
| Gene Bank | Symbol |
F. Change LAA:Scar |
F. Change LC:Scar |
P value | Function |
| NM_006198 | PCP4 | 68.14 | 6.66 | 0.0017 | system development |
| S67238 | MYOSIN | 62.78 | 36.69 | 0.0034 | cytoskeleton/motility |
| NM_004342 | Cald1 | 21.43 | 9.32 | 0.0047 | cytoskeleton/motility |
| NM_013437 | LRP12 | 20.6 | 6.82 | 0.0053 | cellular process |
| AC004010 | AMIGO2 | 19.07 | 10.61 | 0.0021 | cell adhesion |
| AF040254 | OCX | 18.71 | 5.39 | 0.0099 | signal transduction |
| NM_015385 | SORBS1 | 17.44 | 9.26 | 0.0003 | cytoskeleton/motility |
| NM_012278 | ITGB1BP2 | 17.42 | 9.9 | 0.0018 | signal transduction |
| NM_006101 | KNTC2 | 17.33 | 5.23 | 0.0022 | transcription factor |
| NM_001845 | COL4A1 | 16.08 | 5.94 | 0.0029 | cytoskeleton/motility |
| AF104857 | CDC42EP3 | 16.08 | 3.78 | 0.0002 | cytoskeleton/motility |
| AW188131 | DDX17 | 15.65 | 9.11 | 0.0005 | translation factor |
| NM_001057 | TACR2 | 15.6 | 4.51 | 0.0062 | signal transduction |
| AI375002 | ZNF447 | 14.55 | 8.04 | 0.0061 | transcription factor |
| NM_014890 | DOC1 | 14.35 | 5.19 | 0.0002 | proteolysis |
| NM_001784 | CD97 | 13.16 | 6.35 | 0.00004 | signal transduction |
| BF111821 | WSB1 | 12.34 | 7.36 | 0.0024 | signal transduction |
| AW152664 | PNN | 12.19 | 8.26 | 0.003 | transcription factor |
| NM_002380 | MATN2 | 11.86 | 5.62 | 0.0011 | extracellular matrix |
| NM_007362 | NCBP2 | 11.38 | 8.04 | 0.0034 | RNA processing |
| AK023406 | Macf1 | 8.8 | 4.77 | 0.0041 | ECM signaling |
| AF095192 | BAG2 | 8.01 | 4.34 | 0.0018 | apoptosis |
| NM_004196 | CDKL1 | 7.91 | 2.83 | 0.0017 | cell cycle |
| BF512200 | MBNL2 | 7.58 | 3.01 | 0.0014 | muscle differentiaon |
| AW043713 | Sulfl | 6.9 | 0.78 | 0.0039 | hydrolase activity |
| NM_004781 | VAMP3 | 6.76 | 3.02 | 0.0016 | trafficking |
| AI149535 | STAT5B | 5.62 | 3.94 | 0.0043 | transcription factor |
| NM_016277 | RAB23 | 5.61 | 2.68 | 0.0055 | signal transduction |
| AI582238 | TRA1 | 5.13 | 3.46 | 0.0042 | calcium ion binding |
| NM_005722 | ACTR2 | 4.04 | 2.49 | 0.0001 | cytoskeleton/motility |
| AF016005 | RERE | 4.02 | 2.87 | 0.008 | transcription factor |
| AL046979 | TNS1 | 3.65 | 2.14 | 0.0047 | signal transduction |
| NM_005757 | MBNL2 | 3.57 | 0.84 | 0.0049 | muscle development |
| AJ133768 | LDB3 | 3.3 | 1.53 | 0.0056 | cytoskeleton/motility |
| AI650819 | CUL4B | 3.04 | 1.59 | 0.0045 | metabolism |
| AL031602 | MT1K | 0.61 | 0.33 | 0.0086 | cadmium ion binding |
| U85658 | TFAP2C | 0.27 | 0.14 | 0.0083 | transcription factor |
| NM_003790 | TNFRSF25 | 0.19 | 0.11 | 0.007 | apoptosis |
| BC002495 | BAIAP2 | 0.18 | 0.11 | 0.0003 | signal transduction |
| AV691491 | TMEM30B | 0.13 | 0.09 | 0.0093 | cell cycle control |
| AI889941 | COL4A6 | 10.4 | 30.21 | 0.007 | extracellular matrix |
| AW451711 | PBX1 | 14.44 | 18.14 | 0.0001 | transcription factor |
| NM_014668 | GREB1 | 7.18 | 15.94 | 0.0089 | |
| NM_004619 | TRAF5 | 6.47 | 11.46 | 0.0091 | signal transduction |
| NM_005418 | ST5 | 5.83 | 8.1 | 0.0044 | signal transduction |
| BC002811 | SUMO2 | 0.47 | 0.83 | 0.0035 | protein binding |
| AV700891 | ETS2 | 0.28 | 0.54 | 0.0082 | transcription factor |
| AB042557 | PDE4DIP | 0.2 | 0.39 | 0.0019 | signaling |
| NM_014485 | PGDS | 0.17 | 0.31 | 0.0027 | catalytic activity |
| AI984221 | COL5A3 | 0.08 | 0.17 | 0.0011 | extracellular matrix |
| NM_006823 | PKIA | 0.08 | 0.17 | 0.0034 | Kinase regulator |
| AU144284 | IRF6 | 0.04 | 0.15 | 0.0026 | transcription factor |
| NM_000962 | PTGS1 | 0.06 | 0.11 | 0.0046 | catalytic activity |
| NM_022898 | BCL11B | 0.05 | 0.09 | 0.0099 | transcription factor |
| NM_001982 | ERBB3 | 0.02 | 0.06 | 0.0066 | signal transduction |
| NM_002705 | PPL | 0.005 | 0.031 | 0.0073 | hydrolase activity |
| NM_001630 | ANXA8 | 0.006 | 0.02 | 0.0079 | calcium ion binding |
| N74607 | AQP3 | 0.006 | 0.02 | 0.0098 | transporter activity |
| NM_000142 | FGFR3 | 0.007 | 0.009 | 0.01 | Growth factor |
| Receptor |
Partial list of differentially expressed genes from several functional categories in leiomyomas from African Americans and Caucasians as compared to keloids/incesional scars as shown in Fig. 2. The genes were selected based on p ranking of p ≤ 0.01 and following 2-fold cutoff change