Table 8.
Sensitivity to change: mean change-scores* and effect sizes** for changed subjects
| Mean change-score | Effect size—GRS | |||||
|---|---|---|---|---|---|---|
| 0–7 months# | 7–14 months | 0–7 months | 7–14 months | |||
| n = 270*** | P-value | n = 126**** | P-value | n = 270*** | n = 126**** | |
| Generic | ||||||
| RAND | 10.2 | <0.001 | 7.7 | <0.001 | 0.60 | 0.54 |
| FSQ Generic | 7.0 | <0.001 | 4.9 | 0.001 | 0.37 | 0.29 |
| FSQ specific | 9.1 | <0.001 | 6.0 | <0.001 | 0.37 | 0.32 |
| TAIQOL | ||||||
| Sleeping | 9.9 | <0.001 | 7.1 | 0.03 | 0.37 | 0.36 |
| Appetite | 6.8 | 0.001 | 0.0 | 1.0 | 0.28 | 0.00 |
| Problem behaviour | 0.4 | 0.80 | −2.8 | 0.33 | 0.02 | 0.13 |
| Positive mood | 1.5 | 0.30 | 3.9 | 0.11 | 0.06 | 0.25 |
| Liveliness | 2.3 | 0.19 | 1.6 | 0.51 | 0.22 | 0.11 |
| Communication | 2.9 | 0.12 | 1.7 | 0.32 | 0.16 | 0.11 |
| Disease-specific | ||||||
| OM-6 | 16.6 | <0.001 | 11.5 | <0.001 | 0.60 | 0.73 |
| NRS child | 28.3 | <0.001 | 14.2 | <0.001 | 0.91 | 0.64 |
| FFQ | 13.6 | <0.001 | 8.0 | <0.001 | 0.55 | 0.60 |
| NRS caregiver | 19.2 | 0.003 | 9.1 | 0.003 | 0.95 | 0.57 |
* calculated with paired t-test
**calculated with Guyatt’s responsiveness statistic (GRS)
*** n = 114 for TAIQOL subscales and NRS Caregiver; # follow-up interval
**** n = 51 for TAIQOL subscales and NRS Caregiver