Table 2.

Treatment options with antifungal drugs for IPA in critically ill patients in the ICU

Setting	First choice	Alternatives
Primary therapy of IPA	Voriconazole 6 mg/kg q 12 h i. v. on day 1, then 4 mg/kg q 12 h i. v.	Liposomal amphotericin B 3-5 mg/kg/day i. v.
	or	or
	Voriconazole 400 mg q 12 h oral on day 1, then 200 mg q 12 h oral a	Amphotericin B deoxycholate 1 mg/kg/day i. v.
		or
		Caspofungin 70 mg i. v. on day 1, then 50 mg/day i. v. b

^a Oral administration is recommended only in patients with intact intestinal absorption; ^b In patients with moderate to severe hepatic failure, dose reduction is recommended to 35 mg/day i. v.