Table 1.
In vivo cardiac characteristics of rats before and after 8 weeks on an HFD or a LFD
| Start | LFD | HFD | |
|---|---|---|---|
| (n = 24) | (n = 8) | (n = 16) | |
| Physiological parameters | |||
| Body weight (g) | 295 ± 4 | 476 ± 8* | 463 ± 8* |
| Left ventricular mass (mg) | 637 ± 15 | 890 ± 18* | 882 ± 32* |
| LV diastolic parameters | |||
| Posterior wall thickness (mm) | 1.63 ± 0.03 | 1.80 ± 0.07 | 1.71 ± 0.05 |
| Lumen diameter (mm) | 6.92 ± 0.07 | 7.55 ± 0.20* | 7.68 ± 0.10* |
| Interventricular septum wall thickness (mm) | 1.37 ± 0.03 | 1.67 ± 0.08* | 1.54 ± 0.04* |
| Ventricular diameter (mm) | 9.80 ± 0.06 | 10.86 ± 0.13* | 10.89 ± 0.12* |
| LV systolic parameters | |||
| Posterior wall thickness (mm) | 2.93 ± 0.06 | 3.45 ± 0.12* | 3.00 ± 0.08** |
| Lumen diameter (mm) | 3.41 ± 0.10 | 3.32 ± 0.25 | 4.07 ± 0.12*,** |
| Interventricular septum wall thickness (mm) | 2.51 ± 0.05 | 2.85 ± 0.09* | 2.67 ± 0.06 |
| Ventricular diameter (mm) | 8.81 ± 0.07 | 9.82 ± 0.12* | 9.81 ± 0.10* |
| Fractional shortening (%) | 50.8 ± 1.3 | 56.3 ± 2.4* | 47.1 ± 1.7*,** |
| Ejection fraction (%) | 87.5 ± 1.0 | 91.1 ± 1.4 | 84.9 ± 1.0*,** |
Data are means±SE
*p < 0.05 vs start
**p < 0.01 vs LFD