TABLE 1. Pharmacokinetics of S-1 in male Sprague-Dawley rats after i.v. and p.o. administration.

Values are mean ± S.E. (n = 5/dose group).

Pharmacokinetics	Unit	0.1 mg/kg	1 mg/kg	10 mg/kg	30 mg/kg
i.v.
t1/2	min	217	241	248	315
MRT	min	301 ± 20	348 ± 49	363 ± 51	442 ± 170
AUC	min · μg/ml	20.4 ± 0.7	228 ± 32	2549 ± 267	8738 ± 2053
CL	ml/min/kg	5.2 ± 0.2	4.4 ± 0.7	4.0 ± 0.5	3.6 ± 0.7
Vss	ml/kg	1564 ± 149	1532 ± 227	1458 ± 352	1512 ± 216
p.o.		0.1 mg/kg	1 mg/kg	10 mg/kg	30 mg/kg
t1/2	min	322	255	219	254
MRT	min	685 ± 131	542 ± 28	481 ± 43	625 ± 39
Tmax	min	347 ± 126	276 ± 138	288 ± 133	510 ± 151
Cmax	μg/ml	0.014 ± 0.004	0.18 ± 0.06	2.12 ± 0.19	5.01 ± 0.72
AUC	min · μg/ml	12 ± 4	136 ± 19	1412 ± 218	4771 ± 350
CL/F	ml/min/kg	9.5 ± 3.3	7.6 ± 1.0	7.2 ± 1.0	6.3 ± 0.5
Vz/F	ml/kg	4699 ± 2546	2840 ± 468	2294 ± 383	2361 ± 468
Bioavailability	%	59.6	58.0	54.9	55.7