Total body BMD and BMC (n = 7–8) in different treatment groups. A, Total body BMD and BMC measured at 12 wk (before S-4 and DHT treatment) and 20 wk (after S-4 and DHT treatment). B, Changes in total body BMD and BMC during 8 wk treatment with S-4 and DHT (between 12 and 20 wk after ORX). Data are presented as mean ± sem. *, P < 0.05, compared with the intact control group. #, P < 0.05, compared with the vehicle (Veh)-treated ORX group.