Table 2.

Dose taken by adults at withdrawal or last follow-up

Reason for withdrawal	Lamotrigine	Topiramate	Valproate
Inadequate seizure control	n=24; 341 (169), 75–600	n=3; 367 (225), 150–600	n=9; 1600 (896), 500–3000
Unacceptable adverse events	n=9; 119 (99), 25–300	n=23; 172 (110), 50–500	n=13; 838 (240), 500–1200
Inadequate seizure control and unacceptable adverse events	n=2; 200 (0), 200–200	n=11; 177 (109), 50–400	n=8; 1325 (568), 700–2000
Other reason for withdrawal	n=10; 150 (47), 50–200	n=8; 169 (53), 100–250	n=12; 958 (462), 400–2000
Remission of seizures	n=5; 120 (45), 100–200	n=5; 130 (27), 100–150	n=9; 944 (336), 200–1500
Still on randomised drug	n=77; 203 (101), 50–500	n=63; 171 (86), 25–400	n=72; 1081 (463), 300–3000

Data are mean (SD), range.