Figure 4.
Sequence alignment used to build FMO3 homology model prepared using ESPript 2.2 from Expasy Web server [26]. FMO3 sequence is repeated top and bottom for ease of comparison with structural template (24% homology with 2GV8, at top) and with yeast, drosophila, and other human FMOs(26%, 27%, 55%, 57% and 57% homology) (at bottom). Conserved residues are both in black, and starred underneath. Boxed residues are semi-conserved. Motifs are indicated, as are mutated residues characterized in this study.
