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kcat values (min-1) for trimethylamine, benzydamine and methyl p-tolyl sulfide metabolism by FMO3 allelic variants
| FMO3
Variant |
Trimethylamine | Benzydamine | Methyl p-tolyl
Sulfide |
|---|---|---|---|
| Wild Type | 23 ± 1 | 26 ± 3 | 14 ± 1 |
| E158K | 27 ± 4 | 29 ± 4 | 18 ± 1 |
| V257M | 33 ± 1 | 26 ± 2 | 5 ± 0.1 |
| E308G | 18 ± 1 | 33 ± 9 | 18 ± 3 |
| 158K/308G | 30 ± 2 | 36 ± 4 | 12 ± 0.5 |
|
| |||
| N61S | 5.5 ± 0.6 | 2.7 ± 2 | 1.1 ± 0.2 |
| P153L | 2.0 ± 0.1 | 3.4 ± 0.2 | 9 ± 2 |
|
| |||
| M66I | NA | NA | NA |
| R492W | NA | NA | NA |
NA: No activity detected
