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Km values (μM) for trimethylamine, benzydamine and methyl p-tolyl sulfide metabolism by FMO3 allelic variants.
| FMO3
Variant |
Trimethylamine | Benzydamine | Methyl p-tolyl
Sulfide |
|---|---|---|---|
| Wild Type | 31 ± 3 | 43 ± 4 | 248 ± 28 |
| E158K | 27 ± 3 | 33 ± 2 | 181 ± 23 |
| V257M | 27 ± 8 | 121 ± 24 | 207 ± 5 |
| E308G | 29 ± 2 | 39 ± 5 | 219 ± 39 |
| 158K/308G | 22 ± 1 | 47 ± 5 | 301 ± 42 |
|
| |||
| N61S | 205 ± 31 | 335 ± 31 | 264 ± 16 |
| P153L | 30 ± 6 | 73 ± 10 | 242 ± 36 |
|
| |||
| M66I | NA | NA | NA |
| R492W | NA | NA | NA |
NA: No activity detected
