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kcat / Km for trimethylamine, benzydamine and methyl p-tolyl sulfide metabolism by FMO3 allelic variants normalized to wild type FMO3.
| FMO3
Variant |
Trimethylamine | Benzydamine | Methyl p-tolyl
Sulfide |
|---|---|---|---|
| Wild Type | 100 | 100 | 100 |
| E158K | 135 | 145 | 171 |
| V257M | 165 | 36 | 43 |
| E308G | 84 | 140 | 145 |
| 158K/308G | 183 | 127 | 71 |
|
| |||
| N61S | 4 | 1 | 7 |
| P153L | 9 | 8 | 66 |
|
| |||
| M66I | NA | NA | NA |
| R492W | NA | NA | NA |
NA: No activity detected
