Skip to main content
. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Aug 25;17(21):5940–5943. doi: 10.1016/j.bmcl.2007.07.103

Table 2.

Synthesis of 10,10-dioxo-3-carboxamides-thioxanthen-9-ones.a

graphic file with name nihms32118f4.jpg

R Product Yieldb R Product Yieldb
graphic file with name nihms32118t37.jpg 9a 36% graphic file with name nihms32118t38.jpg 9g 29%
graphic file with name nihms32118t39.jpg 9b 46% graphic file with name nihms32118t40.jpg 9h 67%
graphic file with name nihms32118t41.jpg 9c 24% graphic file with name nihms32118t42.jpg 9i 57%
graphic file with name nihms32118t43.jpg 9d 30% graphic file with name nihms32118t44.jpg 9j 56%
graphic file with name nihms32118t45.jpg 9e 31% graphic file with name nihms32118t46.jpg 9k 71%
graphic file with name nihms32118t47.jpg 9f 66%
a

Reactions were run using carboxylic acid-sulfone 8, 1.1 equiv. of amine, 1.1 equiv. of HBTU or BOP and 5.0 equiv. of DIPEA (Diisopropylethyl amine) in 5.0 mL of solvent (CH2Cl2) at RT.

b

Isolated crude yields are reported.