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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2007 Feb 22;18(6):997–1006. doi: 10.1016/j.jasms.2007.02.009

Figure 1. Quantitation by tandem-MS of amino acid stable isotope labeling of newly synthesized proteins.

Figure 1

(a) Trypsin fragments of the protein are separated and concentrated using liquid chromatography before mass spectrometry for detection and quantification of both labeled and unlabeled fragments using MS/MS ions. (b) Diagram of quantitation of labeled and unlabeled Aβ17-28 and graph of labeling curve to calculate synthesis and clearance rates of proteins.

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