. Author manuscript; available in PMC: 2007 Oct 22.

Published in final edited form as: Dev Biol. 2007 Apr 24;306(2):785–796. doi: 10.1016/j.ydbio.2007.04.023

Table 1.

Summary of cardiac NCC phenotypes

	Control (n=8)	PDGFRβ null (n=10)	PDGFRα NCC conditional (n=4)	PDGFRβ NCC conditional (n=13)	PDGFRα/β NCC conditional (n=25)
PTA	n.d.	n.d.	25%	n.d.	100%
REO	n.d.	n.d.	50%	n.d.	100%
VSD	n.d.	80%	75%	n.d.	100%* (22/22)
Thymus#	-			- (3/3)	Hypoplastic (7/7)
Thyroid#	-			- (3/3)	- (7/7)

Data obtained from embryos E14.5-E18.5. Dash indicates organ was phenotypically normal, n.d.-none detected, PTA-persistent truncus arteriosus, REO-retroesophageal origin of the right subclavian artery, and VSD-ventricular septal defects. Controls were littermates that were heterozygous for the PDGFRα conditional and all combinations of PDGFRβ conditional and Wnt1Cre^Tg. *n=22 for VSD because we did not evaluate VSD in the corrosion resin cast aortic arches. ^#PDGFRβ NCC conditional and PDGFRα/β NCC conditional embryos between E14.5 and E16.5.