Fig. 6.

Time course of effects of hypoxia (1% O₂) on adipokine gene expression in human adipocytes.Relative mRNA levels of FIAF, IL-6, leptin, MIF, PAI-1, VEGF (a) and adiponectin, haptoglobin, MCP-1, adipsin, TNF-α (b). Cells were cultured as in Fig. 5; some cells were transferred back to normoxic conditions (21% O₂) for 1 or 16 h after 8 h of hypoxia (8- to 1- and 8- to 16-h groups). Results are means±SE (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001 compared with controls