Figure 5:

Social reward and isolation aversion in juvenile B6 mice. (a) B6 mice differentially approached socially conditioned cues relative to novel cues (*orthogonal contrast for social approach vs. novelty approach, P= 0.03, social approach = time in social environment minus time in novel environment). (b) Unconditioned B6 mice did not respond differentially to the presentation of novel cues in the testing arena (novelty approach = time in novel environment minus time in familiar environment). (c) B6 mice approached novel environments only when the other peripheral compartment of the testing arena contained cues that predicted social isolation (^#orthogonal contrast for isolation aversion vs. novelty approach, P < 0.001, isolation aversion = time in novel environment minus time in isolate environment). Data in each panel are presented as the mean ± SEM.