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In vivo antitumor study against PC-3 cells. The nude mice were subcutaneously injected with PC-3 cells (107 cell/mouse). The tumors were measured every 2 to 3 days. When the tumors had reached a volume of 100 to 140 mm3, the mice were divided into three groups (n = 7), and vehicle (0.5% CMC) or prazosin (3 and 10 mg/kg) was given orally every day. Tumor volume was measured every 2 to 3 days.
