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DNA global hypomethylation analysis in controls (n = 6); preneoplasia-containing lungs on months 3 to 4 (n = 5), months 6 to 8 (n = 5), and months and 10 to 12 (n = 5) after treatment; and in tumors (n = 9). A clear global genomic hypomethylation with an average loss of 25% in mC DNA content only occurs in tumors. Results are expressed as mean ± S.D. Fisher's exact test was applied, and differences were considered significant when P < .05.
