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. 2007 Oct;191(2):99–110. doi: 10.1111/j.1748-1716.2007.01731.x

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© 2007 The Authors Journal compilation © 2007 Scandinavian Physiological Society

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Effect of forskolin on anion exchange functional activity. The effect of forskolin, a cAMP-elevating agent, on anion exchange activity was determined from the extent of pHi changes caused by Cl⁻ removal and addition before and after 5 μm forskolin stimulation (a, b) and diphenylamine-2-carboxylic acid (DPC), a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor (c), on the luminal membrane. The effect of forskolin on basolateral membrane anion exchange activity was determined from the extent of pHi changes caused by Cl⁻ removal and addition before and after 5 μm forskolin stimulation (d, e). The experiment was performed in high extracellular potassium (100 mm K⁺) conditions. The figure shows the mean ± SD of six separate experiments. An asterisk indicates statistical significance (P < 0.05).