Table 2.
Frequency of intron B BCl1, rs2307674 and rs6198 GR SNP genotypes in controls and in the RA cohort stratified by erosive disease, age at disease onset, and carriage of SE alleles
| SE status | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Erosive disease | Age at disease onset | SE negative | SE positive | ||||||
| Genotype | Controls | Present | Absent | < 41 years | ≥ 42 years | Controls | RA cases | Controls | RA cases |
| Intron B BCl1 | (n = 392) | (n = 139) | (n = 25) | (n = 75) | (n = 72) | (n = 71) | (n = 41) | (n = 86) | (n = 154) |
| CC | 147 (37·5) | 58 (41·8) | 7 (28·0) | 32 (42·7) | 31 (43·1) | 29 (40·8) | 16 (39·1) | 29 (33·7) | 60 (39·0) |
| CG | 195 (49·7) | 63 (45·3) | 14 (56·0) | 30 (40·0) | 28 (38·9) | 35 (49·3) | 19 (46·3) | 47 (54·7) | 75 (48·7) |
| GG | 50 (12·8) | 18 (12·9) | 4 (16·0) | 13 (17·3) | 13 (18·0) | 7 (9·9) | 6 (14·6) | 10 (11·6) | 19 (12·3) |
| P-value | – | 0·55 | 0·37 | 0·95 | 0·98 | – | 0·62 | – | 0·62 |
| Rs2307674 | (n = 384) | (n = 135) | (n = 25) | (n = 73) | (n = 72) | (n = 71) | (n = 41) | (n-86) | (n = 150) |
| ttg/ttg | 255 (66·4) | 101 (74·8) | 15 (60·0) | 57 (78·1) | 31 (43·1) | 51 (71·8) | 27 (65·9) | 56 (65·1) | 109 (72·7) |
| ttg/– | 119 (31·0) | 31 (23·0) | 7 (28·0) | 10 (13·7) | 28 (38·9) | 20 (28·2) | 11 (26·8) | 26 (30·2) | 36 (24·0) |
| –/– | 10 (2·6) | 3 (2·2) | 3 (12·0) | 6 (8·2) | 13 (18·0) | 0 (0·0) | 3 (7·3) | 4 (4·7) | 5 (3·3) |
| P-value | – | 0·10 | 0·16 | 0·38 | 0·38 | – | 0·20 | – | 0·22 |
| rs6198 | (n = 390) | (n = 123) | (n = 23) | (n = 66) | (n = 63) | (n = 70) | (n = 37) | (n = 87) | (n = 141) |
| AA | 256 (65·6) | 87 (70·7) | 19 (82·6) | 45 (68·2) | 41 (65·0) | 44 (62·9) | 30 (81·1) | 56 (64·4) | 99 (70·2) |
| AG | 121 (31·1) | 31 (25·2) | 4 (17·4) | 18 (27·3) | 19 (30·2) | 22 (31·4) | 6 (16·2) | 27 (31·0) | 38 (27·0) |
| GG | 13 (3·3) | 5 (4·1) | 0 (0·0) | 3 (4·5) | 3 (4·8) | 4 (5·7) | 1 (2·7) | 4 (4·6) | 4 (2·8) |
| P-value | – | 0·44 | 0·08 | 0·86 | 0·79 | – | 0·05 | – | 0·30 |