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. Author manuscript; available in PMC: 2007 Oct 23.
Published in final edited form as: Xenobiotica. 2004 Mar;34(3):273–280. doi: 10.1080/0049825041008962

Table 1.

Pharmacokinetics of S-4 in rats after intraverous administration.

0.5 mg kg−1 1 mg kg−1 10 mg kg−1 30 mg kg−1
CL (ml min−1 kg−1) 1.92 ± 0.20 2.12 ± 0.07 1.52 ± 0.12 1.00 ± 0.08
Vss (1 kg−1) 0.42 ± 0.06 0.48 ± 0.08 0.44 ± 0.04 0.42 ± 0.14
λz (min−1) 0.0045 ± 0.00046 0.0038 ± 0.00077 0.0031 ± 0.00044 0.0022 ± 0.0008
MRT (min) 222 ± 43 240 ± 45 305 ± 32 423 ± 158
AUC (mg min ml−1) 0.24 ± 0.03 0.46 ± 0.16 6.0 ± 0.5 28 ± 3

Data are mean ± SEM, with five animals per dose group.