Table 2.
Growth velocities (cm/year) and changes in growth velocities before and during the first 2 years of GH treatment. Data are presented as median (range)
| d3/d3 (n = 31) | fl/d3 (n = 65) | fl/fl (n = 144) | (fl/d3 + d3/d3) or D (n = 96) | |
|---|---|---|---|---|
| GV0 | 5·3 (3·0–11·0) | 5·4 (2·0–11·2) | 5·6 (0·8–13·1) | 5·3 (2·0–11·2) |
| GV1 | 9·9 (5·8–13·5) | 9·3 (5·9–14·3) | 9·3 (4·9–15·0) | 9·6 (5·8–14·3) |
| GV2 | 7·5 (4·0–10·6) | 8·0 (5·3–12·1) | 7·7 (3·6–10·8) | 7·9 (4·0–12·1) |
| (GV1 + GV2)/2 | 9·1 (4·9–12·0) | 8·8 (6·7–13·2) | 8·7 (4·9–12·3) | 8·9 (4·9–13·2) |
| Δ(GV1 – GV0) | 4·4 (–3·6 to 8·4) | 4·1 (–1·4 to 7·6) | 3·7 (–5·1 to 10·0) | 4·2 (–3·6 to 8·4)* |
| Δ(GV2 – GV0) | 2·5 (–1·8 to 6·0) | 2·6 (–2·7 to 7·0) | 2·1 (–6·1 to 7·4) | 2·6 (–2·7 to 7·0)† |
| Δ[(GV1 + GV2)/2 – GV0] | 3·4 (–0·3 to 6·9) | 3·2 (–1·9 to 6·4) | 2·8 (–4·6 to 8·5) | 3·2 (–1·9 to 6·9)‡ |
| Studentized residuals GV1 | 0·25 (–2·8 to 2·2) | 0·02 (–2·5 to 3·5) | –0·20 (–3·6 to 2·8)§ | 0·03 (–2·8 to 3·5) |
D, the combination of the two groups fl/d3 and d3/d3; GV0, growth velocity before GH treatment; GV1, growth velocity during the first year of GH treatment; GV2, growth velocity during the second year of GH treatment; (GV1 + GV2)/2, mean growth velocity during the first 2 years of GH treatment.
*
P = 0·038 between fl/fl and D groups.
†
P = 0·041 between fl/fl and D groups.
‡
P = 0·03 between fl/fl and D groups.
§
P = 0·04 indicates significant difference between observed and predicted growth velocity using the SGA prediction model.