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. Author manuscript; available in PMC: 2007 Oct 23.
Published in final edited form as: Circ Res. 2007 Feb 22;100(6):884–893. doi: 10.1161/01.RES.0000260802.75766.00

Figure 4.

Figure 4

DTR-expressing macrophages are found in multiple organs. A through D, Immunohistochemistry for GFP in lung (A), liver (B), and atherosclerotic plaque (C and D) demonstrating GFP-positive macrophages in all organs (arrowheads). C through F, ApoE−/− mice were irradiated and transplanted at 8 weeks of age with CD11b-DTR/apoE−/− marrow and 10 ng/g DT or saline control injected 3 times weekly until 22 weeks. DT reduced the percentage of GFP-positive macrophages (compare F vs control [D]). D and F, Higher-power views of areas outlined in C and E. Scale bars: 200 μm (C and E); and 50 μm (D and F).