Fig 4. SV endocytosis in immature nerve terminals is Ca2+-dependent.
(A) Glutamate release from 2 week old animals was evoked by either 1.3 mM CaCl2 or 1.3 mM BaCl2. Ba2+-dependent glutamate release is displayed (BaCl2 minus CaCl2, n=3 ± SEM). Bar denotes period of BaCl2 addition. (B) FM2-10 was loaded into 2 week old synaptosomes using an S1 stimulation of either 1.3 mM CaCl2 or 1.3 mM BaCl2. The amount of accumulated FM2-10 was quantified with an unloading stimulus of 30 mM KCl (bar). Graph displays Ba2+-dependent FM2-10 loading (BaCl2 minus CaCl2, n=3 ± SEM).