Table 1.

Effects of SC19220 and AH6809 on basal progesterone production and 11β-hydroxysteroid dehydrogenase (11βHSD1) activity. Values are the mean±s.e.m. for three independent experiments with quadruplicate determinations in each experiment (one-way ANOVA)

	Progesterone (pmol/105 cells)	11βHSD1 activity (pmol cortisone/4 h .5×104cells)
Control	2351·1±1028·3	3·7±1·2
+SC19220	2041·6±913·6	3·8±1·1
+AH6809	2712·5±1318·1	2·5±0·4
ANOVA	P=0·161	P=0·158

Progesterone concentrations in culture medium and 11βHSD1 activities in human granulosa–lutein cells were each assessed following a 24- or 4-h incubation respectively with 10 μM SC19220 or 10 μM AH6809.