A, NSF in lysates from NMDA/low Mg2+-treated and untreated hippocampal slices, was assayed for levels of S-nitrosylation. After performing a biotin-switch protocol, S-nitrosylated proteins were isolated and probed for NSF by Western blot. While NSF levels are shown to be equal in total protein fractions, the S-nitrosylated lanes show that NMDA/low Mg2+ increased the amount of modified NSF. B, Quantitation of A. The unnormalized data is graphed in arbitrary units (AU). (n= 3; * p< 0.05)