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. Author manuscript; available in PMC: 2007 Oct 23.
Published in final edited form as: J Biol Chem. 2006 Nov 29;282(5):2891–2898. doi: 10.1074/jbc.M608057200

FIGURE 4. Elimination of sEH protein expression reduces hypotensive effects of LPS challenge in mice.

FIGURE 4

Genotype-specific effects on blood pressure and heart rate in response to LPS challenge. The mean systolic blood pressure (SBP) and heart rate (HR) responses were recorded via tail-cuff in the NIH colony before and periodically after administration of LPS (10 mg/kg, i.p). At 5 h post-LPS administration, the wild type blood pressure and heart rate were below the instrument detection limit (dashed line). Recovery from the acute hypotensive effect of LPS exposure was enhanced among the Ephx2-null mice compared with their wild type counterparts as demonstrated by the attenuated SBP response at both 24 and 48 h post-LPS (single factor ANOVA. *, p < 0.05; #, p < 0.1).