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. Author manuscript; available in PMC: 2007 Oct 23.
Published in final edited form as: Neurochem Int. 2007 May 3;50(7-8):1014–1027. doi: 10.1016/j.neuint.2007.04.019

Figure 1.

Figure 1

PPARγ gene organization (A) and a simplified representation of action of PPAR:RXR heterodimer and ligands in transcriptional process (B). Under the presence of ligands, corepressor is released from PPAR:RXR heterodimer, enabling it to bind to to cofactor HAT complex. With further recruitment of general transcription complexes, transcription process can resume. AF-1; activation function-1. DBD; DNA binding domain. LBD; ligand binding domain. D; hinge domain linking DBD and LBD. PPRE; peroxisome proliferator activated receptor responseive element. HAT; histone acetyltransferase.