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Schematic representations of the interactions between ICP0 and HDAC1/2–CoREST–REST complex and the predicted structure of ICP0. (A) The sequence of ICP0 showing the residues in the binding sites for CoREST (red) and the sequence homologous to residues 3–79 of CoREST (brown). (B) Hypothetical structure of ICP0 in the absence of CoREST (closed conformation) and in the presence of CoREST (open conformation).
