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. 2007 Oct 17;104(43):17069–17074. doi: 10.1073/pnas.0708148104

Fig. 2.

Fig. 2.

Sunitinib-mediated modulations of VEGF, PlGF, and sVEGFR-2 are reversible. Balb/C mice were treated with 7.5, 15, 30, 60, and 120 mg/kg sunitinib daily for two 7-day cycles separated by a break period. Blood was taken retroorbitally before treatment, 24 hours after treatment initiation, after both 7-day treatment cycles, and after the break period. Increased VEGF (A) and PlGF (B), along with decreased sVEGFR-2 (C), were seen after both cycles in 60 and 120 mg/kg groups but returned to baseline after treatment cessation. R/O = Retro-Orbital bleed, C/P = Cardiac Puncture bleed, Tx = Treatment. n = 5 for all groups. Symbols and bars, mean ± SD.