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. 2007 Oct 17;104(43):17069–17074. doi: 10.1073/pnas.0708148104

Fig. 5.

Fig. 5.

VEGF increase and VEGFR-2 decrease in tissue lysates after sunitinib treatment. Lysates made from homogenized tissues of Balb/C mice treated with 120 mg/kg sunitinib for 7 days and tested by ELISA. (A) Levels of VEGF significantly increased in liver, heart, spleen, kidney, and skin but not in bone marrow (BM) or lung. (B) Levels of VEGFR-2 in the same lysates show a significant decrease in expression in the liver, heart, spleen, kidney, BM, and skin. Significant differences from control: *, 0.01 < P < 0.05; **, 0.001 < P < 0.01; ***, P < 0.001. n = 4 for all groups. Values are shown as fold change compared with control and represent pg/ml of protein standardized to milligrams of total protein added to ELISA. Symbols and bars, mean ± SD.