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ZnT8A in prediabetes. (A–C) The cumulative incidence of autoantibodies in 27 subjects followed to T1D is shown for ZnT C-terminal autoreactivity relative to GADA, IA2A, and IAA. (D) ZnT8 C-terminal autoantibodies were determined on the first serum samples to test positive for GADA, IA2, or IAA. Survival analysis compares the disease outcome (mean ± SEM) for ZnT8A-seropositive versus -negative individuals. Subjects remaining in both studies at each time point are indicated.
