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. 2007 Oct 17;104(43):16898–16903. doi: 10.1073/pnas.0702761104

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© 2007 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 4. — NO/RNS regulation of MMP-9 activity. Biphasic and dose-dependent activation/inactivation of pro-MMP-9 by exogenous NO released from Sper/NO. The x axis shows both Sper/NO concentration and nanomolar steady-state NO measured by chemiluminescence. The results represent the mean of n = 3 measurements and are representative of two independent experiments. Symbols indicate statistical significance when compared with untreated control (*, P < 0.01) or when compared with 10 μM Sper/NO (**, P < 0.05; ***, P < 0.001). ND, not done.