Skip to main content
. 2007 Oct 16;104(43):16886–16891. doi: 10.1073/pnas.0708365104

Fig. 5.

Fig. 5.

The logic of sulfur metabolism during the YMC. (A) Temporal expression profiles of sulfur metabolism pathway genes. Note that STR2 and STR3 are clearly up-regulated at the end of the RC phase before the other genes in the pathway, revealing a dynamic switch to the SAM branch of the pathway during RB phase. In the RC phase, sulfur flux is directed back to the GSH branch. Expression data are from ref. 12. (B) A cys4 mutant cannot undergo the YMC. Cells containing a disruption in the 3′ UTR of cystathionine β-synthase (CYS4) do not exhibit metabolic cycles during continuous growth. Shown is the dissolved oxygen trace of a cys4 mutant for ≈22 h after the start of continuous mode. x-axis tick marks correspond to 5-h intervals. Mutations in human cystathionine β-synthase have been linked to various disorders of the brain.