Figure 4. PAR-1 −/− mice show no deficits in nociceptive responses to heat or electrical shock.

(A) Both wild-type (n=11) and PAR1−/− (n=12) mice exhibited similar latencies to hind-paw licking at 52 °C using conventional hot plate test. (B) Wild-type and PAR1−/− mice also displayed similar thresholds for flinching, jumping and vocalizing in tests of the electrical shock threshold (n=12 per genotype). Data are presented as mean ± SEM.