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. Author manuscript; available in PMC: 2008 Jun 15.
Published in final edited form as: Cell. 2007 Jun 15;129(6):1037–1038. doi: 10.1016/j.cell.2007.06.001

Figure 1. A Protein Tyrosine Kinase Family Drama.

Figure 1

Depicted are autoinhibited assemblies of Src, ZAP-70, and FAK. The structures are aligned based on their kinase domains; important regulatory linker segments are shown in orange. Inhibition is mediated by docking of the regulatory domains to the “back” side of the kinase domain in Src and ZAP-70 but by occlusion of the catalytic cleft on the opposite side by the FERM domain in FAK.