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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1982 Jun;63(3):269–277.

Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline.

M A Rossi, S V Carillo
PMCID: PMC2040630  PMID: 6212077

Abstract

This study examined the effect of long-term administration of reserpine, an adrenergic blocking agent, on cardiac hypertrophy in animals with severe iron deficiency anaemia. This condition was induced by feeding rats on an iron-deficient diet for 30 days from the time of weaning. Anaemia was indicated by lowering of blood haemoglobin levels. Reserpine was administered i.p. (0.15 mg/kg body wt) every day during the experiment. Marked cardiac hypertrophy, as indicated by increase heart weight and increased size of cardiac muscle cells, was evidenced in iron-deficient rats, while the heart weights and myocardial cell size of drug-treated anaemic rats were in the normal range. The successful prevention of cardiac hypertrophy in anaemic iron-deficient rats by reserpine administration supports the hypothesis that noradrenaline plays a key role in the cardiac-hypertrophy process in iron deficiency anaemia.

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Selected References

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  1. Anton A. H., Sayre D. F. Possible sources of error in solvent extraction procedures for catecholamines. Eur J Pharmacol. 1968 Nov;4(4):435–440. doi: 10.1016/0014-2999(68)90031-9. [DOI] [PubMed] [Google Scholar]
  2. Caldarera C. M., Giorgi P. P., Casti A. The effect of noradrenaline on polyamine and RNA synthesis in the chick embryo. J Endocrinol. 1970 Jan;46(1):115–116. doi: 10.1677/joe.0.0460115. [DOI] [PubMed] [Google Scholar]
  3. Grossman W. Cardiac hypertrophy: useful adaptation or pathologic process? Am J Med. 1980 Oct;69(4):576–584. doi: 10.1016/0002-9343(80)90471-4. [DOI] [PubMed] [Google Scholar]
  4. Grove D., Nair K. G., Zak R. Biochemical correlates of cardiac hypertrophy. 3. Changes in DNA content; the relative contributions of polyploidy and mitotic activity. Circ Res. 1969 Oct;25(4):463–471. doi: 10.1161/01.res.25.4.463. [DOI] [PubMed] [Google Scholar]
  5. Iversen L. L., De Champlain J., Glowinski J., Axelrod J. Uptake, storage and metabolism of norepinephrine in tissues of the developing rat. J Pharmacol Exp Ther. 1967 Sep;157(3):509–516. [PubMed] [Google Scholar]
  6. Iwata H., Kariya K., Fujimoto S. Effect of compounds affecting the adrenergic mechanism on cell growth and division of Tetrahymena pyriformis W. Jpn J Pharmacol. 1969 Jun;19(2):275–281. doi: 10.1254/jjp.19.275. [DOI] [PubMed] [Google Scholar]
  7. Laks M. M., Morady F. Norepinephrine--the myocardial hypertrophy hormone? Am Heart J. 1976 May;91(5):674–675. doi: 10.1016/s0002-8703(76)80156-1. [DOI] [PubMed] [Google Scholar]
  8. MANNA L., HAUGE S. M. A possible relationship of vitamin B13 to orotic acid. J Biol Chem. 1953 May;202(1):91–96. [PubMed] [Google Scholar]
  9. Mallov S. Effect of sympathomimetic drugs on protein synthesis in rat heart. J Pharmacol Exp Ther. 1973 Dec;187(3):482–494. [PubMed] [Google Scholar]
  10. Rossi M. A., Carillo S. V., Oliveira J. S. The effect of iron deficiency anemia in the rat on catecholamine levels and heart morphology. Cardiovasc Res. 1981 Jun;15(6):313–319. doi: 10.1093/cvr/15.6.313. [DOI] [PubMed] [Google Scholar]
  11. Sasayama S., Ross J., Jr, Franklin D., Bloor C. M., Bishop S., Dilley R. B. Adaptations of the left ventricle to chronic pressure overload. Circ Res. 1976 Mar;38(3):172–178. doi: 10.1161/01.res.38.3.172. [DOI] [PubMed] [Google Scholar]
  12. Spann J. F., Jr, Buccino R. A., Sonnenblick E. H., Braunwald E. Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res. 1967 Sep;21(3):341–354. doi: 10.1161/01.res.21.3.341. [DOI] [PubMed] [Google Scholar]
  13. Spann J. F., Jr, Covell J. W., Eckberg D. L., Sonnenblick E. H., Ross J., Jr, Braunwald E. Contractile performance of the hypertrophied and chronically failing cat ventricle. Am J Physiol. 1972 Nov;223(5):1150–1157. doi: 10.1152/ajplegacy.1972.223.5.1150. [DOI] [PubMed] [Google Scholar]
  14. Varat M. A., Adolph R. J., Fowler N. O. Cardiovascular effects of anemia. Am Heart J. 1972 Mar;83(3):415–426. doi: 10.1016/0002-8703(72)90445-0. [DOI] [PubMed] [Google Scholar]
  15. Voorhess M. L., Stuart M. J., Stockman J. A., Oski F. A. Iron deficiency anemia and increased urinary norepinephrine excretion. J Pediatr. 1975 Apr;86(4):542–547. doi: 10.1016/s0022-3476(75)80144-2. [DOI] [PubMed] [Google Scholar]
  16. Wagner A., Fortier N., Giroux A., Lukes J., Snyder L. M. Catecholamines in adult iron deficiency patients. Experientia. 1979 May 15;35(5):681–682. doi: 10.1007/BF01960396. [DOI] [PubMed] [Google Scholar]
  17. Wikman-Coffelt J., Parmley W. W., Mason D. T. The cardiac hypertrophy process. Analyses of factors determining pathological vs. physiological development. Circ Res. 1979 Dec;45(6):697–707. doi: 10.1161/01.res.45.6.697. [DOI] [PubMed] [Google Scholar]
  18. Wood W. G., Lindenmayer G. E., Schwartz A. Myocardial synthesis of ribonucleic acid. I. Stimulation by isoproterenol. J Mol Cell Cardiol. 1971 Oct;3(2):127–138. doi: 10.1016/0022-2828(71)90011-3. [DOI] [PubMed] [Google Scholar]
  19. Yamaguchi N., de Champlain J., Nadeau R. Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog. Circ Res. 1975 May;36(5):662–668. doi: 10.1161/01.res.36.5.662. [DOI] [PubMed] [Google Scholar]

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