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. 2007 Jun 25;104(27):11189–11191. doi: 10.1073/pnas.0704691104

Table 1.

The Niles, IL, computation

m P(14400, 9000, m) Monte Carlo P value
6 0.000005 0.000 1.000000
7 0.095395 0.096 0.999995
8 0.664954 0.678 0.904605
9 0.937864 0.944 0.335046
10 0.990843 0.993 0.062136
11 0.998788 0.998 0.009157
12 0.999852 0.999 0.001212

The computation of the exact values required <5 sec on a personal computer running algebra system Maple (available from the authors upon request). The Monte Carlo computations required ≈30 min. In both the Monte Carlo simulations and the exact calculations, we observed the expected rapid change of P values as m increases, emphasizing the need for exact P value calculations as disscussed in the text.