Fig. 3.

Pinching alters input–output relationships, and a compartmental model qualitatively replicates all effects of pinching. (A) APs evoked by a series of step current injections (values above the traces) applied to a Purkinje cell before (black) and during (red) dendritic pinching. (B) f-I plot for the Purkinje cell in A before and during pinching. (C) (Top Left) Purkinje cell used in the modeling. (Top Right) Calculated single AP in this cell before (black) and during (red) simulated pinching. (Middle and Bottom) Trains of simulated APs in response to current steps before and during pinching. (D) f-I plots calculated from simulations like those in C.